At Annai Systems we have been busy overcoming some persistent problems of big data that stand in the way of unleashing the full power of genomics in research and medicine. Ours are not the glamorous problems of perfecting, analyzing and interpreting genomic data. We leave that to hundreds of brilliant bioinformaticians. No, ours are the nagging operational problems of holding the data, protecting it, accessing it, searching it, transferring it, sharing it, and excising only the segments of it that really interest researchers at a moment in time. Oh, and aggregating datasets massive enough to allow algorithms to find an elusive signal emitted by clinically significant clusters of heterogeneous rare variants. We are the network engineers in hardhats and jumpsuits who are crushing these operational problems with industrial-strength solutions built to support the era of genomic medicine.